Thomas Mercher Selected Research

Acute Megakaryoblastic Leukemia (Leukemia, Megakaryocytic)

1/2017	Pediatric Acute Megakaryoblastic Leukemia: Multitasking Fusion Proteins and Oncogenic Cooperations.
1/2017	ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.
1/2017	Molecular pathways driven by ETO2-GLIS2 in aggressive pediatric leukemia.
8/2012	Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.
10/2008	OTT-MAL is a deregulated activator of serum response factor-dependent gene expression.
7/2007	A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia.

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Thomas Mercher Research Topics

Disease

10	Neoplasms (Cancer) 01/2022 - 07/2006
8	Leukemia 02/2022 - 10/2006
6	Acute Megakaryoblastic Leukemia (Leukemia, Megakaryocytic) 01/2017 - 07/2007
4	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2019 - 07/2006
4	Fibrosis (Cirrhosis) 04/2009 - 06/2006
3	Acute Erythroblastic Leukemia (Erythroleukemia) 05/2021 - 01/2020
2	Genetic Translocation (Chromosomal Translocation) 01/2022 - 07/2018
2	Hematologic Neoplasms (Hematological Malignancy) 10/2018 - 11/2013
2	Hyperplasia 10/2006 - 06/2006
2	Splenomegaly 07/2006 - 06/2006
2	Hypersensitivity (Allergy) 07/2006 - 06/2006
1	Lymphoma (Lymphomas) 01/2022
1	Waldenstrom Macroglobulinemia (Macroglobulinemia) 01/2019
1	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 10/2018
1	Carcinogenesis 07/2018
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2018
1	Polyploidy 08/2012
1	Thrombocytopenia (Thrombopenia) 04/2009
1	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 03/2009
1	Thrombocytosis (Thrombocythemia) 07/2006
1	Myeloproliferative Disorders (Myeloproliferative Disorder) 07/2006
1	Leukocytosis (Pleocytosis) 06/2006
1	beta-Thalassemia (Cooley's Anemia) 11/2005
1	Polycythemia Vera 04/2005
1	Primary Myelofibrosis (Myelosclerosis) 04/2005
1	Essential Thrombocythemia 04/2005

Drug/Important Bio-Agent (IBA)

5	Proteins (Proteins, Gene)FDA Link 12/2020 - 07/2007
4	Transcription Factors (Transcription Factor)IBA 05/2021 - 01/2017
3	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 02/2022 - 04/2005
3	Oncogene Proteins (Oncogene Protein)IBA 01/2017 - 01/2013
3	Phosphotransferases (Kinase)IBA 08/2012 - 07/2006
3	Reticulin (Reticular Fiber)IBA 10/2006 - 06/2006
2	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 04/2012
2	Messenger RNA (mRNA)IBA 01/2018 - 11/2005
2	Tyrosine (L-Tyrosine)FDA Link 07/2007 - 07/2006
2	CytokinesIBA 07/2006 - 06/2006
1	Tyrosine Kinase InhibitorsIBA 02/2022
1	Anaplastic Lymphoma KinaseIBA 01/2022
1	Cell Surface ReceptorsIBA 01/2022
1	ChromatinIBA 05/2021
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 12/2020
1	trametinibIBA 01/2020
1	Vincristine (Oncovin)FDA LinkGeneric 01/2020
1	Proto-Oncogene Proteins c-etsIBA 01/2019
1	Biological ProductsIBA 01/2019
1	Janus Kinase InhibitorsIBA 10/2018
1	Cytokine Receptors (Cytokine Receptor)IBA 10/2018
1	Circular RNAIBA 07/2018
1	EnzymesIBA 01/2018
1	ibrutinibIBA 01/2018
1	ApolipoproteinsIBA 01/2018
1	CytidineIBA 01/2018
1	Single-Stranded DNA (DNA, Single Stranded)IBA 01/2018
1	AICDA (activation-induced cytidine deaminase)IBA 01/2018
1	Immunoglobulins (Immunoglobulin)IBA 01/2018
1	Peptides (Polypeptides)IBA 01/2018
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 11/2013
1	Aurora Kinase AIBA 08/2012
1	MLN 8237IBA 08/2012
1	CytosineIBA 04/2012
1	Thrombopoietin ReceptorsIBA 04/2009
1	Macrophage Colony-Stimulating FactorIBA 07/2007
1	Interleukin-3 (Interleukin 3)IBA 07/2007
1	Thrombopoietin (c-mpl Ligand)IBA 07/2006
1	Erythropoietin FDA Link 06/2006
1	Hemoglobins (Hemoglobin)IBA 06/2006
1	beta-Globins (beta Globin)IBA 11/2005

Therapy/Procedure

4	Bone Marrow Transplantation (Transplantation, Bone Marrow) 11/2013 - 10/2006
1	Therapeutics 01/2022
1	Drug Therapy (Chemotherapy) 01/2020
1	Transjugular Intrahepatic Portasystemic Shunt 01/2019